Cell Metabolism· Fotios Karagiannis, Maria Rafailia Theodorou, Fabian Nikolka, Maria Doverman, Dhruvi Shah, Chantal Wientjens, Timothy R. McCulloch, Ronja Kardinal, David Colon, Jelena Zurkovic, Jiangyan Yu, Julia Anna Noras, Patricia Weiss, Roman Rombo, Tim Sparwasser, Zeinab Abdullah, Felix Meissner, Christoph Thiele, Jan Hasenauer, Dagmar Wachten, Karsten Hiller, Christoph Wilhelm·· 2026-09-23AI 评分20
Cell Metabolism：脂肪 ILC2 依赖 ACC1 维持代谢健康，补充 NR 可挽救其缺失
Adipose ILC2s depend on acetyl-CoA carboxylase 1 to maintain metabolic health
AI 导读
Karagiannis 与 Theodorou 等人在 Cell Metabolism 报告，肥胖中的脂质过载通过乙酰辅酶 A 羧化酶 1（ACC1）损伤脂肪组织 2 型固有淋巴细胞（ILC2）。小鼠中敲除 ACC1 会破坏柠檬酸穿梭与 NAD+/NADH 平衡，导致 ILC2 丢失和脂肪组织肥大；补充烟酰胺核糖（NR）可挽救 ACC1 缺失并恢复 ILC2 与脂肪组织稳态。
来源：Cell Metabolism · cell.com