Aging Cell· Se Eun Park,
Eun Roh,
Jae Woo Park,
Seong Jun Kim,
So Yeon Jeong,
Chae Beom Park,
Hyo Sun Lim,
Ji Soo Kim,
Mun Gyeom Kim,
Myeong Ju Kim,
Young In Cho,
Wontae Jeong,
Gil Myoung Kang,
Sang‐Yeob Kim,
Se Hee Min,
Min‐Seon Kim·· 23 天前AI 评分23
下丘脑神经元初级纤毛 NAD+ 信号网络调控溶酶体稳态与代谢衰老
A Cilia–Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging
AI 导读
下丘脑神经元中 NAD+ 耗竭会缩短初级纤毛并阻碍 CHMP4B 向溶酶体转运，损害 TRPML1 介导的钙信号与溶酶体应激反应。老年小鼠下丘脑 NAD+ 不足表现出纤毛缩短和溶酶体应激表型，热量限制可恢复上述改变，并部分通过纤毛依赖机制改善衰老相关代谢功能障碍。
来源：Aging Cell · onlinelibrary.wiley.com