Aging Cell· Ziwei Wang,
Yoichi Takami,
Cheng Wang,
Yoshitaka Kase,
Hiroshi Koriyama,
Jittoku Ihara,
Yu Guo,
Weidong Liu,
Nanxiang Yin,
Lisha Yi,
Daisuke Nawa,
Hikari Takeshita,
Shuko Takeda,
Akitoshi Hara,
Toshimasa Takahashi,
Munehisa Shimamura,
Hironori Nakagami,
Yasufumi Kaneda,
Koichi Yamamoto·· 4 天前AI 评分25
Aging Cell：脑微血管内皮衰老相关 α-突触核蛋白缺失破坏紧密连接与血脑屏障完整性
Senescence‐Associated Loss of α‐Synuclein in Brain Microvascular Endothelium Compromises Tight Junctions and Disrupts Blood–Brain Barrier Integrity
AI 导读
人脑微血管内皮细胞（HBMECs）复制性衰老及 siRNA 敲低 SNCA 均诱导 p16/p53 激活、SIRT1/eNOS 下降和 BACE1 升高，导致 occludin、ZO-1 丢失、通透性增加，共沉默 BACE1 可恢复紧密连接蛋白并恢复正常通透性。
来源：Aging Cell · onlinelibrary.wiley.com