Cell Metabolism· Xingyu Zhou, Chuanfa Liu, Wenchao Wei, Xueliang Wang, Yasi Pan, Ying Jiao, Shiyu Li, Yating Zhang, Harry Cheuk-Hay Lau, Ruyi Zhang, Dingwu Li, Alvin Ho-Kwan Cheung, Minghua Zheng, Wen Pan, Chi Chun Wong, Vincent Wai-Sun Wong, Jun Yu, Xiang Zhang·· 2026-10-02AI 评分22
Cell Metabolism：根霉通过生成犬尿喹啉酸促进MASLD相关肝细胞癌
Fungus Rhizopus arrhizus promotes MASLD-associated hepatocellular carcinoma through generating kynurenic acid
AI 导读
周等人发现肠道真菌根霉（Rhizopus arrhizus）在MASLD相关肝细胞癌中具促肿瘤作用，其产生的犬尿喹啉酸直接结合肿瘤细胞并激活致癌MAPK信号通路。阻断这一宿主-真菌相互作用可抑制MASLD-HCC发展，提示潜在治疗方向。
来源：Cell Metabolism · cell.com