Cell Metabolism· Mengqi Zheng, Yunjiao Zhai, Yanbo Yu, Jing Shen, Shuzheng Chu, Enrico Focaccia, Wenyu Tian, Sui Wang, Xuesong Liu, Xi Yuan, Yue Wang, Lixiang Li, Bingcheng Feng, Zhen Li, Xiaohuan Guo, Ju Qiu, Cuijuan Zhang, Jiajie Hou, Yiyuan Sun, Xiaoyun Yang, Xiuli Zuo, Mathias Heikenwalder, Yanqing Li, Detian Yuan, Shiyang Li·· 2026-10-13AI 评分30
Cell Metabolism：TNF 破坏肠道胆汁酸耐受，决定结肠炎进展并限制英夫利昔单抗应答
TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response
AI 导读
Cell Metabolism 发表研究显示，TNF 通过破坏肠道胆汁酸耐受推动结肠炎进展，并限制抗 TNF 药物英夫利昔单抗（infliximab）的疗效。该研究为理解结肠炎进展机制及部分患者对英夫利昔单抗应答有限提供了新线索。
来源：Cell Metabolism · cell.com