Cell Metabolism· Suyao Li, Dong Guo, Qingqing Yang, Yizhi Cao, Yu Dong, Xiaoming Jiang, Xinyao Tian, Dou Nie, Lihui Wu, Qingang Wu, Xuxiao He, Yanyan Hu, Rongxuan Zhu, Ning Zhu, Shudi Luo, Yinan Shen, Yuhao Wang, Zhexu Chi, Ying Yuan, Daqian Xu, Weilin Wang, Yuan Ding, Zhimin Lu·· 23 天前AI 评分22
Cell Metabolism：丙酸促进 MHC I 类抗原呈递并增强抗肿瘤免疫
Propionate promotes MHC class I antigen presentation and anti-tumor immunity
AI 导读
Li 等人在 Cell Metabolism 报告，丙酸通过结合 E3 泛素连接酶 STUB1、阻断 MHC I 类分子的泛素化与降解，增强肿瘤 MHC I 类抗原呈递。这一非代谢功能促进 CD8+ T 细胞免疫并提升抗 PD-1 疗效，提示膳食丙酸或产丙酸益生菌可作为改善肿瘤免疫治疗的潜在策略。
来源：Cell Metabolism · cell.com